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日期:2024-04-19
Apoptosis (/ˌæpəˈtoʊsɪs/;[2][3] from Ancient Greek ἀπό apo, "by, from, of, since, than" and πτῶσις ptōsis, "fall") is the process of programmed cell death (PCD) that may occur in multicellular organisms.[4] Biochemical events lead to characteristic cell c...
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日期:2024-04-25
Figure 2 | Nutrient sensing and inflammation. The signalling pathways that sense and respond to three basic nutrients, free fatty acids, glucose and amino acids, are depicted. Many pathways that monitor nutrient availability, such as those of mammalian ta...
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日期:2024-04-19
Ciliogenesis Once a cell enters quiescence, it must go through a series of events to realize a fully matured cilium. All cilia subtypes must conform to a basic structure. The elemental cilium is composed of the basal body (BB) that is located at the apica...
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日期:2024-04-21
PI3K Pathway Aberrations in Human Cancer When cancer cell lines are addicted to RTKs, usually PI3K or MEK pathway inhibitors inhibit growth. However, it is not clear if PI3K inhibitors alone will be successful in the clinic. Jeffrey A. Engelman ......
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日期:2024-04-23
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status, expressed almost universally in eukaryotes as heterotrimeric complex ... Allosteric Activation in the Absence of Thr172 Phosphorylation Since phosphorylation of AM...
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日期:2024-04-23
Introduction Hydrogen peroxide (H 2 O 2) is a ubiquitous oxidant present in all aerobic organisms. Since its first identification in a living cell, H 2 O 2 was considered a toxic byproduct of aerobic metabolism, something that cells had to remove [1]. If ...
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日期:2024-04-23
Autophagy is an evolutionarily conserved catabolic process that recycles nutrients upon starvation and maintains cellular energy homeostasis. Its acute regulation by nutrient-sensing signalling pathways is well described, but its longer-term transcription...
Cancer & Metabolism | Full text | Hypoxia signaling pathways in cancer metabolism: the importance of
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日期:2024-04-22
In addition, other interactions, which are not directly connected with the oxygen sensing process, but which modulate the HIF pathway through effects on the transcription, translation, post-translational modification and protein interactions of one or ......