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日期:2025-05-14
A synonymous substitution (often called a silent substitution though they are not always silent) is the evolutionary substitution of one base for another in an exon of a gene coding for a protein, such that the produced amino acid sequence is not modified...
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日期:2025-05-12
BIOINFORMATICS APPLICATIONS NOTE Vol. 18 no. 6 2002 Pages 886–887 Synonymous–non-synonymous mutation rates between sequences containing ambiguous nucleotides (Syn-SCAN) Matthew J. Gonzales1, Jonathan M. Dugan2 and Robert W. Shafer1,∗ ......
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日期:2025-05-15
Mutations within exons are responsible for aberrant splicing of pre-mRNA in several human disease genes and in some viral systems. Nonsense, missense, and even synonymous mutations can induce aberrant skipping of the mutant exon, producing nonfunctional ....
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1. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13481-6. doi: 10.1073/pnas.1304227110. Epub 2013 Jul 30. Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma. Gartner JJ, Parker SC, Prickett TD, Dutton-Regester K ......
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A nonsynonymous substitution is a nucleotide mutation that alters the amino acid sequence of a protein. It is contrasted with synonymous substitutions which do not alter amino acid sequences. As nonsynonymous substitutions result in a biological change in...
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日期:2025-05-11
A mutation is a genetic change that causes new and different characteristics, like the mutation on the dog's DNA that makes its tail shorter than its ancestors' tails....
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Synonyms words that are the same part of speech and that have meanings containing identical elements; the differing elements of the meanings are consistently neutralized in certain contexts. Thus, synonyms are words that are distinguishable only by such ....
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We here close our picturings of the Rocky Mountains and their wild inhabitants, and of the wild life that prevails there; which we have been anxious to fix on record, because we are aware that this singular state of things is full of mutation, and must so...